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Chemical Structure : TAK-438 free base
CAS No.: 881681-00-1
Catalog No.: PC-42022Not For Human Use, Lab Use Only.
A novel potent, oral potassium-competitive acid blocker (P-CAB) that potently inhibits H+,K+-ATPase with IC50 of 19 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $56 | In stock | |
| 500 mg | $155 | In stock | |
| 1g | $225 | In stock |
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A novel potent, oral potassium-competitive acid blocker (P-CAB) that potently inhibits H+,K+-ATPase with IC50 of 19 nM; completely inhibits basal and 2-deoxy-d-glucose-stimulated gastric acid secretion in rats (4mg/kg, p.o.); increases the pH of gastric perfusate to a higher value, and sustains longer than those of lansoprazole or SCH28080; a clinical candidate for the treatment of gastroesophageal reflux disease (GERD), peptic ulcer, and other acid-related diseases.
Ulcer
Phase 3 Clinical
| M.Wt | 345.3912 | |
| Formula | C17H16FN3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)- |
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1. Arikawa Y, et al. J Med Chem. 2012 May 10;55(9):4446-56.
2. Hori Y, et al. J Pharmacol Exp Ther. 2010 Oct;335(1):231-8.
3. Shin JM, et al. J Pharmacol Exp Ther. 2011 Nov;339(2):412-20.
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