Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : TAK-632
CAS No.: 1228591-30-7
Catalog No.: PC-72530Not For Human Use, Lab Use Only.
TAK-632 (TAK632) is a potent, selective pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAF V600E and BRAF WT, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
TAK-632 (TAK632) is a potent, selective pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAF V600E and BRAF WT, respectively.
TAK-632 suppresses RAF activity in BRAF wild-type cells with minimal RAF paradoxical activation.
TAK-632 induces RAF dimerization but inhibits the kinase activity of the RAF dimer.
TAK-632 demonstrates potent antiproliferative effects both on NRAS-mutated melanoma cells and BRAF-mutated melanoma cells with acquired resistance to BRAF inhibitors through NRAS mutation or BRAF truncation.
TAK-632 exhibits synergistic antiproliferative effects combined with MEK inhibitor TAK-733.
TAK-632 also is a selective RIPK3 inhibitor (RIPK3 Kd =81 nM), > 60-fold selectivity against RIPK3 than RIPK1.
| M.Wt | 554.520 | |
| Formula | C27H18F4N4O3S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
100 mM in DMSO (55.4 mg/mL) |
|
| Chemical Name/SMILES |
N-(7-Cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide |
|
1. Nakamura A, et al. Cancer Res. 2013 Dec 1;73(23):7043-55.
2. Grasso M, et al. J Med Chem. 2018 Jun 14;61(11):5034-5046.
3. Chen X, et al. Br J Pharmacol. 2019 Jun;176(12):2095-2108.
4. Abt ER, et al. Cell Chem Biol. 2020 Feb 20;27(2):197-205.e6.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
