Catalog No.: PC-42599Not For Human Use, Lab Use Only.
TAK-715 is a potent, selective, orally active p38α MAPK inhibitor with IC50 of 7.1 nM, also inhibits casein kinase I (CK1δ/ε) to regulate activation of Wnt/β-catenin signaling.
TAK-715 is a potent, selective, orally active p38α MAPK inhibitor with IC50 of 7.1 nM, also inhibits casein kinase I (CK1δ/ε) to regulate activation of Wnt/β-catenin signaling.
TAK-715 displays >20-fold selectvity over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1.
TAK-715 inhibits LPS-stimulated release of TNF-alpha from THP-1 with IC50 of 48 nM.
TAK-715 exerts significant efficacy in rat adjuvant-induced arthritis model.
