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TAK-715

Chemical Structure : TAK-715

CAS No.: 303162-79-0

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TAK-715 (TAK 715, TAK715)

Catalog No.: PC-42599Not For Human Use, Lab Use Only.

TAK-715 is a potent, selective, orally active p38α MAPK inhibitor with IC50 of 7.1 nM.

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5 mg $78 In stock
10 mg $118 In stock
25 mg $198 In stock
50 mg $288 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TAK-715 is a potent, selective, orally active p38α MAPK inhibitor with IC50 of 7.1 nM.
TAK-715 displays >20-fold selectvity over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1.
TAK-715 inhibits LPS-stimulated release of TNF-alpha from THP-1 with IC50 of 48 nM.
TAK-715 exerts significant efficacy in rat adjuvant-induced arthritis model.

Physicochemical Properties

M.Wt 399.508
Formula C24H21N3OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-

References

1. Miwatashi S, et al. J Med Chem. 2005 Sep 22;48(19):5966-79.

2. Verkaar F, et al. Chem Biol. 2011 Apr 22;18(4):485-94.

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