Catalog No.: PC-49641Not For Human Use, Lab Use Only.
TAS-205 (Pizuglanstat, TAS205) is a potent, specific hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with IC50 of 55.8 nM, does not inhibit LPGDS at 100 uM.
TAS-205 (Pizuglanstat) monohydrate is a potent, specific hematopoietic prostaglandin D synthase (H-PGDS) inhibitor with IC50 of 55.8 nM, does not inhibit LPGDS at 100 uM.
TAS-205 did not affect the activities of 174 enzymes, including 10 arachidonic acid-related enzymes such as cyclooxygenase (COX)-1, COX-2, and LTC4 synthase or the binding of 164 receptors.
TAS-205 inhibited PGD2 increase of calcium ionophore A23187-stimulated rat basophilic RBL-2H3 cells and human basophilic KU812 cells with IC50 of 181.3 nM and 78.3 nM, respectively, TAS-205 inhibited PGD2 production induced by the cross-linking of IgE on RBL-2H3 cells with IC50 of 238.4 nM.
TAS-205 (30 mg/kg, p.o.) suppressed late phase nasal obstruction in our guinea pig model, TAS-205 alone and in combination with montelukast showed inhibitory effects on eosinophil infiltration into the nasal cavity.
