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Chemical Structure : TBBz
CAS No.: 577779-57-8
Catalog No.: PC-61326Not For Human Use, Lab Use Only.
TBBz is a potent, selective and ATP-competitive CK2 inhibitor with Ki of 0.5-1 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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TBBz is a potent, selective and ATP-competitive CK2 inhibitor with Ki of 0.5-1 uM.
TBBz weakly inhibits CK1 (about 100-fold less potent), and has no activity for PKA and PKC.
TBBz decreases the activity of GBM-initiating cell regulator β-catenin, reduces cell growth, decreases tumor size, and increases survival rates in GBM xenograft mouse models.
| M.Wt | 433.72 | |
| Formula | C7H2N2Br4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4,5,6,7-Tetrabromo-1H-benzimidazole |
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1. Zień P, et al. Biochem Biophys Res Commun. 2003 Jun 20;306(1):129-33.
2. Zien P, et al. Biochim Biophys Acta. 2005 Dec 30;1754(1-2):271-80.
3. Nitta RT, et al. Oncogene. 2015 Jul;34(28):3688-99.
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