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TD-139

Chemical Structure : TD-139

CAS No.: 1450824-22-2

TD-139 (GB0139, TD139, Olitigaltin)

Catalog No.: PC-45754Not For Human Use, Lab Use Only.

TD-139 (GB0139, Olitigaltin) is a highly potent, selecitve inhibitor of Galectin-3 (Gal-3) carbohydrate binding domain with Ki of 14 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TD-139 (GB0139, Olitigaltin) is a highly potent, selecitve inhibitor of Galectin-3 (Gal-3) carbohydrate binding domain with Ki of 14 nM.
TD-139 (GB0139, Olitigaltin) reduces TGF-β1-induced β-catenin translocation to the nucleus, blocks β-catenin phosphorylation in vitro and in vivo.
TD-139 (GB0139, Olitigaltin) attenuates the late-stage progression of lung fibrosis in murine models.
TD-139 (GB0139, Olitigaltin) attenuates liver injury and milder infiltration of IFNγ- and IL-17- and -4-producing CD4(+) T cells, increases IL-10-producing CD4(+) T cells and F4/80(+) CD206(+) alternatively activated macrophages and prevents the apoptosis of liver-infiltrating MNCs in WT C57BL/6 mice.

Physicochemical Properties

M.Wt 648.635
Formula C28H30F2N6O8S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 1 mg/mL (Need ultrasonic); H2O: < 5 mg/mL; Ethanol: 0.1 mg/mL (Need ultrasonic and warming)

Chemical Name/SMILES

β-D-Galactopyranoside, 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-β-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-

References

1. Mackinnon AC, et al. Am J Respir Crit Care Med. 2012 Mar 1;185(5):537-46.

2. Volarevic V, et al. Hepatology. 2012 Jun;55(6):1954-64.

3. Volarevic V, et al. Eur J Immunol. 2015 Feb;45(2):531-43.

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