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Chemical Structure : TD-139
CAS No.: 1450824-22-2
Catalog No.: PC-45754Not For Human Use, Lab Use Only.
TD-139 (GB0139, Olitigaltin) is a highly potent, selecitve inhibitor of Galectin-3 (Gal-3) carbohydrate binding domain with Ki of 14 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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TD-139 (GB0139, Olitigaltin) is a highly potent, selecitve inhibitor of Galectin-3 (Gal-3) carbohydrate binding domain with Ki of 14 nM.
TD-139 (GB0139, Olitigaltin) reduces TGF-β1-induced β-catenin translocation to the nucleus, blocks β-catenin phosphorylation in vitro and in vivo.
TD-139 (GB0139, Olitigaltin) attenuates the late-stage progression of lung fibrosis in murine models.
TD-139 (GB0139, Olitigaltin) attenuates liver injury and milder infiltration of IFNγ- and IL-17- and -4-producing CD4(+) T cells, increases IL-10-producing CD4(+) T cells and F4/80(+) CD206(+) alternatively activated macrophages and prevents the apoptosis of liver-infiltrating MNCs in WT C57BL/6 mice.
| M.Wt | 648.635 | |
| Formula | C28H30F2N6O8S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 1 mg/mL (Need ultrasonic); H2O: < 5 mg/mL; Ethanol: 0.1 mg/mL (Need ultrasonic and warming) |
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| Chemical Name/SMILES |
β-D-Galactopyranoside, 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-β-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio- |
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1. Mackinnon AC, et al. Am J Respir Crit Care Med. 2012 Mar 1;185(5):537-46.
2. Volarevic V, et al. Hepatology. 2012 Jun;55(6):1954-64.
3. Volarevic V, et al. Eur J Immunol. 2015 Feb;45(2):531-43.
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