TG100572 is a potent, dual receptor tyrosine kinase/Src kinase inhibitor with IC50 of 2-16 nM for VEGFR, FGFR and PDGFR, 0.1-5 nM for Src family.
TG100572 inhibits vascular endothelial cell proliferation in vitro (ED50=610 nM) and blocks VEGF-induced phosphorylation of ERK, induces apoptosis.
TG100572 significant suppresses laser-induced choroidal neovascularization (CNV) in a murine model.
