Catalog No.: PC-49574Not For Human Use, Lab Use Only.
TG11-77 is a potent, selective, brain-permeable and orally available antagonist of the prostaglandin E2 (PGE2) receptor subtype EP2 with KB value of 9.7 nM.
TG11-77 is a potent, selective, brain-permeable and orally available antagonist of the prostaglandin E2 (PGE2) receptor subtype EP2 with KB value of 9.7 nM.
TG11-77 is selective for EP2 over DP1, EP4, and IP receptors (KBs=7,320, 5,300, and >10,000 nM, respectively).
TG11-77 inhibits the expression of genes encoding COX-2, IL-1β, and IL-6 induced by LPS and the EP2 receptor agonist ONO-AE1-259-01 in mouse BV-2 microglia expressing human EP2 receptors.
TG11-77 eliminates the profound cognitive deficit in Y-maze performance after SE and reduces delayed mortality and microgliosis, with a minimum effective i.p. dose (as free base) of 8.8 mg/kg.
