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Chemical Structure : TG11-77
Catalog No.: PC-49574Not For Human Use, Lab Use Only.
TG11-77 is a potent, selective, brain-permeable and orally available antagonist of the prostaglandin E2 (PGE2) receptor subtype EP2 with KB value of 9.7 nM.
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TG11-77 is a potent, selective, brain-permeable and orally available antagonist of the prostaglandin E2 (PGE2) receptor subtype EP2 with KB value of 9.7 nM.
TG11-77 is selective for EP2 over DP1, EP4, and IP receptors (KBs=7,320, 5,300, and >10,000 nM, respectively).
TG11-77 inhibits the expression of genes encoding COX-2, IL-1β, and IL-6 induced by LPS and the EP2 receptor agonist ONO-AE1-259-01 in mouse BV-2 microglia expressing human EP2 receptors.
TG11-77 eliminates the profound cognitive deficit in Y-maze performance after SE and reduces delayed mortality and microgliosis, with a minimum effective i.p. dose (as free base) of 8.8 mg/kg.
| M.Wt | 436.944 | |
| Formula | C23H25ClN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Radhika Amaradhi, et al. J Med Chem. 2020 Feb 13;63(3):1032-1050.
2. Nicholas H Varvel , et al. Neuropharmacology. 2022 Nov 30;224:109356.
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