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TG554

Chemical Structure : TG554

CAS No.:

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TG554 (TG-554)

Catalog No.: PC-22237Not For Human Use, Lab Use Only.

TG554 is a potent, selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor with IC50 of 5.6 nM, suppresses leukotriene (LT) biosynthesis at low µM concentrations.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TG554 is a potent, selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor with IC50 of 5.6 nM, suppresses leukotriene (LT) biosynthesis at low µM concentrations.
    TG554 does not inhibit other essential enzymes in the AA cascade, namely 5-LOX, COX-1, and COX-2 at 10 uM.
    TG554 significantly inhibits the generation of PGE2 with IC50 of 30 nM in stimulated M1-MDMs.
    TG554 (10 uM) strongly impaires 5-LOX product biosynthesis in ionophore-activated neutrophils.

    Physicochemical Properties

    M.Wt 440.28
    Formula C22H15Cl2N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-Chloro-N-(5-{4-[(4-chlorophenyl)methoxy]phenyl}-1,3,4-oxadiazol-2-yl)benzamide

    References

    1. Tuğçe Gür Maz, et al. Bioorg Chem. 2024 Apr 16:147:107383.

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