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Chemical Structure : TG554
Catalog No.: PC-22237Not For Human Use, Lab Use Only.
TG554 is a potent, selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor with IC50 of 5.6 nM, suppresses leukotriene (LT) biosynthesis at low µM concentrations.
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TG554 is a potent, selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor with IC50 of 5.6 nM, suppresses leukotriene (LT) biosynthesis at low µM concentrations.
TG554 does not inhibit other essential enzymes in the AA cascade, namely 5-LOX, COX-1, and COX-2 at 10 uM.
TG554 significantly inhibits the generation of PGE2 with IC50 of 30 nM in stimulated M1-MDMs.
TG554 (10 uM) strongly impaires 5-LOX product biosynthesis in ionophore-activated neutrophils.
| M.Wt | 440.28 | |
| Formula | C22H15Cl2N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tuğçe Gür Maz, et al. Bioorg Chem. 2024 Apr 16:147:107383.
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