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Chemical Structure : TG6-10-1
CAS No.: 1415716-58-3
Catalog No.: PC-45111Not For Human Use, Lab Use Only.
TG6-10-1 is a potent and selective antagonist of prostaglandin E2 receptor subtype EP2 with Kb of 17.8 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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TG6-10-1 is a potent and selective antagonist of prostaglandin E2 receptor subtype EP2 with Kb of 17.8 nM.
TG6-10-1 displays >300-fold selectivity over EP3, EP4, and IP receptors, 100-fold selectivity over EP1, 25-fold selectivity over FP and TP, and 10-fold selectivity over DP1 receptors.
TG6-10-1 completely recapitulates the effects of conditional ablation of COX-2 from principal forebrain neurons, accelerates recovery from weight loss, reduces brain inflammation, prevention of blood-brain barrier opening, and neuroprotection in the hippocampus, without modifying seizures acutely in the mouse pilocarpine model of SE.
| M.Wt | 448.4349 | |
| Formula | C23H23F3N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-Propenamide, N-[2-[2-(trifluoromethyl)-1H-indol-1-yl]ethyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)- |
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1. Jiang J, et al. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3591-6.
2. Rojas A, et al. Neuropharmacology. 2015 Jun;93:15-27.
3. Rojas A, et al. Neuropharmacology. 2016 Nov;110(Pt A):419-30.
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