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TG8-69

Chemical Structure : TG8-69

CAS No.: 2281765-16-8

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TG8-69 (TG 8-69)

Catalog No.: PC-35786Not For Human Use, Lab Use Only.

TG8-69 is a peripherally restricted, highly potent, selective, aqueous-soluble EP2 antagonist with Kb of 48.5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TG8-69 is a peripherally restricted, highly potent, selective, aqueous-soluble EP2 antagonist with Kb of 48.5 nM.
    TG8-69 inhibits PGE2 induced EP2 receptor activation in a concentration-dependent manner in cAMP mediated TR-FRET based functional EP2 assay, inhibits the binding of radiolabeled H3-PGE2 to EP2 receptors with Ki of 135 nM.
    TG8-69 displays >1000-fold selectivity ober other Gαs-coupled prostanoid receptors, DP1, EP4, and IP.
    TG8-69 demonstrates anti-inflammatory properties.

    Physicochemical Properties

    M.Wt 346.394
    Formula C19H18N6O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(2-(2-methyl-1H-indol-3-yl)ethyl)-4-(1H-tetrazol-5-yl)benzamide

    References

    1. Ganesh T, et al. Mol Pharm. 2018 Nov 6. doi: 10.1021/acs.molpharmaceut.8b00764.

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