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Chemical Structure : TG8-69
Catalog No.: PC-35786Not For Human Use, Lab Use Only.
TG8-69 is a peripherally restricted, highly potent, selective, aqueous-soluble EP2 antagonist with Kb of 48.5 nM.
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TG8-69 is a peripherally restricted, highly potent, selective, aqueous-soluble EP2 antagonist with Kb of 48.5 nM.
TG8-69 inhibits PGE2 induced EP2 receptor activation in a concentration-dependent manner in cAMP mediated TR-FRET based functional EP2 assay, inhibits the binding of radiolabeled H3-PGE2 to EP2 receptors with Ki of 135 nM.
TG8-69 displays >1000-fold selectivity ober other Gαs-coupled prostanoid receptors, DP1, EP4, and IP.
TG8-69 demonstrates anti-inflammatory properties.
| M.Wt | 346.394 | |
| Formula | C19H18N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ganesh T, et al. Mol Pharm. 2018 Nov 6. doi: 10.1021/acs.molpharmaceut.8b00764.
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