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Chemical Structure : TL02-59
CAS No.: 1315330-17-6
Catalog No.: PC-35102Not For Human Use, Lab Use Only.
TL02-59 is a potent, selective, orally available inhibitor of Src-family kinase Fgr IC50 of 0.03 nM, also inhibits Lyn and Hck with IC50 of 0.1 and 160 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $478 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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TL02-59 is a potent, selective, orally available inhibitor of Src-family kinase Fgr IC50 of 0.03 nM, also inhibits Lyn and Hck with IC50 of 0.1 and 160 nM, respectively.
TL02-59 inhibits Syk, Fes, Flt3-WT and Flt3-ITD with IC50 of 470, 290, 633 and 440 nM, inhibits MV4-11 AML cell growth with IC50 of <1 nM.
TL02-59 completely eliminates leukemic cells from the spleen and peripheral blood while significantly reducing bone marrow engraftment at 10 mg/kg in mouse xenograft model of AML.
| M.Wt | 609.65 | |
| Formula | C32H34F3N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-((6,7-dimethoxyquinazolin-4-yl)oxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide |
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1. Weir MC, et al. ACS Chem Biol. 2018 May 15. doi: 10.1021/acschembio.8b00154.
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