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TLSC702

Chemical Structure : TLSC702

CAS No.: 748786-57-4

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TLSC702 (TLSC-702, TLSC 702)

Catalog No.: PC-63307Not For Human Use, Lab Use Only.

TLSC702 is a novel potent inhibitor of human glyoxalase I (hGLO I) with IC50 of 2.0 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TLSC702 is a novel potent inhibitor of human glyoxalase I (hGLO I) with IC50 of 2.0 uM.
    TLSC702 inhibits the proliferation of human leukemia HL-60 cells and induces apoptosis in a dose-dependent manner.
    TLSC702 more significantly inhibits the proliferation of human lung cancer NCI-H522 cells, which highly express GLO I, than that of GLO I lower-expressing human lung cancer NCI-H460 cells.

    Physicochemical Properties

    M.Wt 325.382
    Formula C18H15NO3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(benzo[d]thiazol-2-yl)-4-(4-methoxyphenyl)but-3-enoic acid

    References

    1. Takasawa R, et al. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4337-42.

    2. Takasawa R, et al. Biol Pharm Bull. 2016;39(5):869-73.

    3. Shimada N, et al. Arch Biochem Biophys. 2018 Jan 15;638:1-7.

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