Chemical Structure : TNI-97
CAS No.:
2790425-52-2
TNI-97
Catalog No.: PC-24898Not For Human Use, Lab Use Only.
TNI-97 is a potent, highly selective and orally bioavailable HDAC6 inhibitor with IC50 of 0.2 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TNI-97 is a potent, highly selective and orally bioavailable HDAC6 inhibitor with IC50 of 0.2 nM.
TNI-97 demonstrates minimal to no inhibition against class IIa HDACs (HDAC4, 5, 7, 9) and class IV HDAC (HDAC11), as well as HDAC10.
TNI-97 demonstrates more potent on-target activity and better selectivity over clinical candidate ACY-1215.
TNI-97 dose-dependently inhibits the MDA-MB-453 colony formation with GI50 of 0.2 uM.
TNI-97 induces apoptosis in MDA-MB-453 cells in a concentration-dependent manner.
TNI-97 also upregulated cleaved forms of GSDMD and GSDME, two biomarkers of pyroptosis, as well as phosphorylation of MLKL and RIPK3, two inducers of necroptosis.
TNI-97 (40 and 20 mg/kg, oral) demonstrated antitumor activity in the MDA-MB-453 CDX model.
Physicochemical Properties
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M.Wt
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416.36
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Formula
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C19H15F3N6O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-Hydroxy-4-((3-(1-methyl-1H-benzo[d][1,2,3]triazol-5-yl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)benzamide
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References
1. Wang S, et al. J Med Chem. 2025 Jul 3. doi: 10.1021/acs.jmedchem.5c00278.
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