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Chemical Structure : TP-0903
CAS No.: 1341200-45-0
Catalog No.: PC-43297Not For Human Use, Lab Use Only.
TP-0903 (Dubermatinib, TP0903) is a potent, selective, orally bioavailable Axl inhibitor with IC50 of 27 nM inhibits cell viability of pncreactic cancer cells (PSN1) with IC50 of 6 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg (Free Sample) | $18 | In stock | |
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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TP-0903 (Dubermatinib, TP0903) is a potent, selective, orally bioavailable Axl inhibitor with IC50 of 27 nM inhibits cell viability of pncreactic cancer cells (PSN1) with IC50 of 6 nM.
TP-0903 also strongly inhibits related TAM family members MER and TYRO3, Aurora A/B (IC50=3.0/12.4 nM), JAK2, ALK, ABL1, and CHEK1 in a panel of 75 kinases (11/75 >50% inhibition at 200 nM)。
TP-0903 induces robust levels of apoptosis in CLL B-cells from all the CLL patients with mean LD50 of 0.14 uM; inhibits neuroblastoma cell growth, reduces NB cells intravasation in vitro and in vivo and enhances the sensitivity to conventional chemotherapy.
| M.Wt | 516.0587 | |
| Formula | C24H30ClN7O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
Benzenesulfonamide, 2-[[5-chloro-2-[[4-[(4-methyl-1-piperazinyl)methyl]phenyl]amino]-4-pyrimidinyl]amino]-N,N-dimethyl- |
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1. Sinha S, et al. Clin Cancer Res. 2015 May 1;21(9):2115-26.
2. Park IK, et al. Leukemia. 2015 Dec;29(12):2382-9.
3. Mollard A, et al. ACS Med Chem Lett. 2011 Dec 8;2(12):907-912.
4. Aveic S, et al. Eur J Pharmacol. 2018 Jan 5;818:435-448.
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