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Tandutinib

Chemical Structure : Tandutinib

CAS No.: 387867-13-2

Tandutinib (MLN-518, MLN518, CT53518, MLN0518, MLN-0518, CT-53518)

Catalog No.: PC-42447Not For Human Use, Lab Use Only.

Tandutinib (MLN-518, CT53518) is a potent inhibitor of FLT3, Kit and PDGFR with IC50 of 0.22, 0.17 and 0.2 uM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Tandutinib (MLN-518, CT53518) is a potent inhibitor of FLT3, Kit and PDGFR with IC50 of 0.22, 0.17 and 0.2 uM, respectively.
Tandutinib (MLN-518, CT53518) displays 15-20-fold less potent activity against CSF-1R.
Tandutinib (MLN-518, CT53518) inhibits IL-3-independent cell growth and FLT3-ITD autophosphorylation with IC50 of 10-100 nM, induces apoptosis and inhibits FLT3-ITD phosphorylation, cellular proliferation and signaling through MAPK and PI3K pathways.
Tandutinib (MLN-518, CT53518) exhibits ativity in murine models of FLT3-ITD-mediated disease.

Physicochemical Properties

M.Wt 562.703
Formula C31H42N6O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 36 mg/mL

Chemical Name/SMILES

1-Piperazinecarboxamide, 4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-

References

1. Kelly LM, et al. Cancer Cell. 2002 Jun;1(5):421-32.

2. Pandey A, et al. J Med Chem. 2002 Aug 15;45(17):3772-93.

3. Griswold IJ, et al. Blood. 2004 Nov 1;104(9):2912-8.

4. Clark JJ, et al. Blood. 2004 Nov 1;104(9):2867-72.

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