Tandutinib (MLN-518, CT53518) is a potent inhibitor of FLT3, Kit and PDGFR with IC50 of 0.22, 0.17 and 0.2 uM, respectively.
Tandutinib (MLN-518, CT53518) displays 15-20-fold less potent activity against CSF-1R.
Tandutinib (MLN-518, CT53518) inhibits IL-3-independent cell growth and FLT3-ITD autophosphorylation with IC50 of 10-100 nM, induces apoptosis and inhibits FLT3-ITD phosphorylation, cellular proliferation and signaling through MAPK and PI3K pathways.
Tandutinib (MLN-518, CT53518) exhibits ativity in murine models of FLT3-ITD-mediated disease.
