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Chemical Structure : Tandutinib
CAS No.: 387867-13-2
Catalog No.: PC-42447Not For Human Use, Lab Use Only.
Tandutinib (MLN-518, CT53518) is a potent inhibitor of FLT3, Kit and PDGFR with IC50 of 0.22, 0.17 and 0.2 uM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $58 | In stock | |
| 100 mg | $88 | In stock | |
| 250 mg | $138 | In stock | |
| 1 g | Get quote |
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Tandutinib (MLN-518, CT53518) is a potent inhibitor of FLT3, Kit and PDGFR with IC50 of 0.22, 0.17 and 0.2 uM, respectively.
Tandutinib (MLN-518, CT53518) displays 15-20-fold less potent activity against CSF-1R.
Tandutinib (MLN-518, CT53518) inhibits IL-3-independent cell growth and FLT3-ITD autophosphorylation with IC50 of 10-100 nM, induces apoptosis and inhibits FLT3-ITD phosphorylation, cellular proliferation and signaling through MAPK and PI3K pathways.
Tandutinib (MLN-518, CT53518) exhibits ativity in murine models of FLT3-ITD-mediated disease.
| M.Wt | 562.703 | |
| Formula | C31H42N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 36 mg/mL |
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| Chemical Name/SMILES |
1-Piperazinecarboxamide, 4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]- |
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1. Kelly LM, et al. Cancer Cell. 2002 Jun;1(5):421-32.
2. Pandey A, et al. J Med Chem. 2002 Aug 15;45(17):3772-93.
3. Griswold IJ, et al. Blood. 2004 Nov 1;104(9):2912-8.
4. Clark JJ, et al. Blood. 2004 Nov 1;104(9):2867-72.
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