Catalog No.: PC-21204Not For Human Use, Lab Use Only.
Teduglutide (ALX-0600, h[Gly(2)]GLP-2) is a dipeptidyl peptidase IV resistant GLP-2 analogue, prolongs the intestinotrophic properties of GLP-2 in animal models, activates the expression of nuclear receptor subfamily 4 group a member 1 (NR4A1)/nur77 and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis.
Teduglutide (ALX-0600, h[Gly(2)]GLP-2) is a dipeptidyl peptidase IV resistant GLP-2 analogue, prolongs the intestinotrophic properties of GLP-2 in animal models, activates the expression of nuclear receptor subfamily 4 group a member 1 (NR4A1)/nur77 and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis.
Physicochemical Properties
M.Wt
3752.13
Formula
C164H252N44O55S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
HGDGSFSDEMNTILDNLAARDFINWLIQTKITD
References
1. Jeppesen PB, et al. Gut. 2005 Sep;54(9):1224-31.
2. Booth C, et al. Cell Prolif. 2004 Dec;37(6):385-400.
