Catalog No.: PC-21650Not For Human Use, Lab Use Only.
Tefinostat (CHR-2845) is a monocyte/macrophage targeted pan histone deacetylase (HDAC) inhibitor, which is cleaved into the active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1).
Tefinostat (CHR-2845) is a monocyte/macrophage targeted pan histone deacetylase (HDAC) inhibitor, which is cleaved into the active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat show sselective high sensitivity against monocytoid leukaemias with EC50 of 57 nM to MV411 (M4, FLT3-ITD). Tefinostat spares normal bone marrow progenitor cells. hCE-1 expression levels dictate efficacy of Tefinostat in monocytic leukaemias. Tefinostat is synergistic with cytarabine.
