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Toceranib

Chemical Structure : Toceranib

CAS No.: 356068-94-5

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Toceranib (SU 11654;PHA 291639;SU11654;SU-11654;PHA-291639;PHA291639)

Catalog No.: PC-42528Not For Human Use, Lab Use Only.

An ATP-competitive inhibitor of RTKs, including VEGFR, FGFR, PDGFR, and Kit.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

An ATP-competitive inhibitor of RTKs, including VEGFR, FGFR, PDGFR, and Kit; inhibits phosphorylation of WT Kit in the presence of stem cell factor at concentrations as low as 0.01 uM; disrupts function of all forms of mutant Kit in cells.

Physicochemical Properties

M.Wt 396.4579
Formula C22H25FN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Pyrrole-3-carboxamide, 5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-

References

1. Liao AT, et al. Blood. 2002 Jul 15;100(2):585-93.

2. London CA, et al. Clin Cancer Res. 2003 Jul;9(7):2755-68.

3. London C, et al. Vet Comp Oncol. 2012 Sep;10(3):194-205.

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