Catalog No.: PC-42528Not For Human Use, Lab Use Only.
Toceranib (PHA 291639, SU11654) is a potent, ATP-competitive inhibitor of RTKs, including VEGFR, FGFR, PDGFR, and Kit, has Ki of 5 and 6 nM for PDGFRβ and Flk-1/KDR.
Toceranib (PHA 291639, SU11654) is a potent, ATP-competitive inhibitor of RTKs, including VEGFR, FGFR, PDGFR, and Kit, has Ki of 5 and 6 nM for PDGFRβ and Flk-1/KDR.
Toceranib inhibits phosphorylation of WT Kit in the presence of stem cell factor at concentrations as low as 0.01 uM.
Toceranib disrupts function of all forms of mutant Kit in cells.
