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Chemical Structure : Tofogliflozin
Catalog No.: PC-44120Not For Human Use, Lab Use Only.
Tofogliflozin (CSG-452) is a potent, highly selective SGLT2 inhibitor with Ki of 2.9, 14.9, and 6.4 nM against human, rat, and mouse SGLT2, respectively.
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Tofogliflozin (CSG-452) is a potent, highly selective SGLT2 inhibitor with Ki of 2.9, 14.9, and 6.4 nM against human, rat, and mouse SGLT2, respectively.
Tofogliflozin displays high selectivity over human SGLT2 versus human SGLT1, SGLT6, and sodium/myo-inositol transporter 1.
Tofogliflozin increases renal glucose clearance and lowered the blood glucose level in Zucker diabetic fatty rats, also improves postprandial glucose excursion.
Tofogliflozin reduces glycated hemoglobin and improved glucose tolerance in the oral glucose tolerance test in vivo.
| M.Wt | 386.44 | |
| Formula | C22H26O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Suzuki M, et al. J Pharmacol Exp Ther. 2012 Jun;341(3):692-701.
2. Ohtake Y, et al. J Med Chem. 2012 Sep 13;55(17):7828-40.
3. Nagata T, et al. Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E414-23.
4. Nagata T, et al. Br J Pharmacol. 2013 Oct;170(3):519-31.
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