Tofogliflozin | SGLT2 inhibitor | Probechem Biochemicals

Chemical Structure : Tofogliflozin

Tofogliflozin (CSG452, CSG-452)

Catalog No.: PC-44120Not For Human Use, Lab Use Only.

Tofogliflozin (CSG-452) is a potent, highly selective SGLT2 inhibitor with Ki of 2.9, 14.9, and 6.4 nM against human, rat, and mouse SGLT2, respectively.

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Biological Activity

Tofogliflozin (CSG-452) is a potent, highly selective SGLT2 inhibitor with Ki of 2.9, 14.9, and 6.4 nM against human, rat, and mouse SGLT2, respectively.
Tofogliflozin displays high selectivity over human SGLT2 versus human SGLT1, SGLT6, and sodium/myo-inositol transporter 1.
Tofogliflozin increases renal glucose clearance and lowered the blood glucose level in Zucker diabetic fatty rats, also improves postprandial glucose excursion.
Tofogliflozin reduces glycated hemoglobin and improved glucose tolerance in the oral glucose tolerance test in vivo.

Physicochemical Properties

M.Wt	386.44
Formula	C22H26O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Spiro[isobenzofuran-1(3H),2'-[2H]pyran]-3',4',5'-triol, 6-[(4-ethylphenyl)methyl]-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)-, (1S,3'R,4'S,5'S,6'R)-

References

1. Suzuki M, et al. J Pharmacol Exp Ther. 2012 Jun;341(3):692-701.

2. Ohtake Y, et al. J Med Chem. 2012 Sep 13;55(17):7828-40.

3. Nagata T, et al. Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E414-23.

4. Nagata T, et al. Br J Pharmacol. 2013 Oct;170(3):519-31.

Tofogliflozin (CSG452, CSG-452)

Biological Activity

Physicochemical Properties

References

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