Tofogliflozin hydrate | SGLT2 inhibitor

Chemical Structure : Tofogliflozin hydrate

CAS No.: 1201913-82-7

Tofogliflozin hydrate (CSG452 hydrate, CSG-452 hydrate)

Catalog No.: PC-43518Not For Human Use, Lab Use Only.

Tofogliflozin (CSG-452) hydrate is a potent, highly selective SGLT2 inhibitor with Ki of 2.9, 14.9, and 6.4 nM against human, rat, and mouse SGLT2, respectively.

Packing	Price	Stock
5 mg	$98	In stock
10 mg	$148	In stock
25 mg	$268	In stock
50 mg	$458	In stock
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Biological Activity

Tofogliflozin (CSG-452) hydrate is a potent, highly selective SGLT2 inhibitor with Ki of 2.9, 14.9, and 6.4 nM against human, rat, and mouse SGLT2, respectively.
Tofogliflozin (CSG-452) displays high selectivity over human SGLT2 versus human SGLT1, SGLT6, and sodium/myo-inositol transporter 1.
Tofogliflozin (CSG-452) increases renal glucose clearance and lowered the blood glucose level in Zucker diabetic fatty rats, also improves postprandial glucose excursion.
Tofogliflozin (CSG-452) reduces glycated hemoglobin and improved glucose tolerance in the oral glucose tolerance test in vivo.

Physicochemical Properties

M.Wt	404.45
Formula	C22H28O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Spiro[isobenzofuran-1(3H),2'-[2H]pyran]-3',4',5'-triol, 6-[(4-ethylphenyl)methyl]-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)-, hydrate (1:1), (1S,3'R,4'S,5'S,6'R)-

References

1. Suzuki M, et al. J Pharmacol Exp Ther. 2012 Jun;341(3):692-701.

2. Ohtake Y, et al. J Med Chem. 2012 Sep 13;55(17):7828-40.

3. Nagata T, et al. Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E414-23.

4. Nagata T, et al. Br J Pharmacol. 2013 Oct;170(3):519-31.

Tofogliflozin hydrate (CSG452 hydrate, CSG-452 hydrate)

Biological Activity

Physicochemical Properties

References

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