Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Tofogliflozin hydrate
CAS No.: 1201913-82-7
Catalog No.: PC-43518Not For Human Use, Lab Use Only.
Tofogliflozin (CSG-452) hydrate is a potent, highly selective SGLT2 inhibitor with Ki of 2.9, 14.9, and 6.4 nM against human, rat, and mouse SGLT2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Tofogliflozin (CSG-452) hydrate is a potent, highly selective SGLT2 inhibitor with Ki of 2.9, 14.9, and 6.4 nM against human, rat, and mouse SGLT2, respectively.
Tofogliflozin (CSG-452) displays high selectivity over human SGLT2 versus human SGLT1, SGLT6, and sodium/myo-inositol transporter 1.
Tofogliflozin (CSG-452) increases renal glucose clearance and lowered the blood glucose level in Zucker diabetic fatty rats, also improves postprandial glucose excursion.
Tofogliflozin (CSG-452) reduces glycated hemoglobin and improved glucose tolerance in the oral glucose tolerance test in vivo.
| M.Wt | 404.45 | |
| Formula | C22H28O7 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Spiro[isobenzofuran-1(3H),2'-[2H]pyran]-3',4',5'-triol, 6-[(4-ethylphenyl)methyl]-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)-, hydrate (1:1), (1S,3'R,4'S,5'S,6'R)- |
|
1. Suzuki M, et al. J Pharmacol Exp Ther. 2012 Jun;341(3):692-701.
2. Ohtake Y, et al. J Med Chem. 2012 Sep 13;55(17):7828-40.
3. Nagata T, et al. Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E414-23.
4. Nagata T, et al. Br J Pharmacol. 2013 Oct;170(3):519-31.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
