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Chemical Structure : Trovafloxacin
CAS No.: 147059-72-1
Catalog No.: PC-21765Not For Human Use, Lab Use Only.
Trovafloxacin is a broad-spectrum quinolone antibiotic, blocks the DNA gyrase and topoisomerase IV activity, also is a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with IC50 of 4 uM for PANX1 inward current.
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|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
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| 100 mg | Get quote |
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Trovafloxacin is a broad-spectrum quinolone antibiotic, blocks the DNA gyrase and topoisomerase IV activity, also is a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with IC50 of 4 uM for PANX1 inward current.
Trovafloxacin does not inhibit connexin 43 gap junction or PANX2.
Trovafloxacin induces apoptosis and increases leakage of lactate dehydrogenase (LDH) in HepG2 cells, increases expression of early NF-κB-related factors A20 and IκBα.
Trovafloxacin is equally active against both penicillin-susceptible and -resistant pneumococci, with MICs of 0.06-0.25 mg/mL.
| M.Wt | 416.36 | |
| Formula | C20H15F3N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7-((1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid |
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1. Poon IK, et al. Nature. 2014 Mar 20;507(7492):329-34.
2. Gootz TD, et al. Antimicrob Agents Chemother. 1996 Dec;40(12):2691-7.
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