UCHL1 inhibitor 27 (IMP-1711-S) is a potent, selective, covalent UCHL1 inhibitor with IC50 of 90 nM.
UCHL1 inhibitor 27 (IMP-1711-S) demonstrated exquisite selectivity in a cross-screening against 20 DUBs.
UCHL1 inhibitor 27 (IMP-1711-S) demonstrated >50% fibroblast–myofibroblast transition (FMT) inhibition (IC50=100 nM) in idiopathic pulmonary fibrosis (IPF), as well as αSMA inhibition.
UCHL1 inhibitor 27 (IMP-1711-S) is a powerful and selective probe to explore UCHL1 activity with potential application to substrate identification, mode of action studies, and cellular target profiling.
IMP-1711-S inhibited the production of IL-1β in a concentration-dependent manner in PMA-differentiated THP-1 cells and hiPSC-derived microglia.
IMP-1711-S potently inhibited gasdermin D (GSDMD) cleavage, the release of lactate dehydrogenase (LDH), and blocked pyroptotic cell death induced by Nig.
IMP-1711-S markedly downregulated the formation of NLRP3 specks in a concentration-dependent manner in HEK293 cells