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Chemical Structure : UCHL1 inhibitor 27
Catalog No.: PC-72220Not For Human Use, Lab Use Only.
UCHL1 inhibitor 27 is a potent, selective, covalent UCHL1 inhibitor with IC50 of 90 nM.
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UCHL1 inhibitor 27 (IMP-1711-S) is a potent, selective, covalent UCHL1 inhibitor with IC50 of 90 nM.
UCHL1 inhibitor 27 (IMP-1711-S) demonstrated exquisite selectivity in a cross-screening against 20 DUBs.
UCHL1 inhibitor 27 (IMP-1711-S) demonstrated >50% fibroblast–myofibroblast transition (FMT) inhibition (IC50=100 nM) in idiopathic pulmonary fibrosis (IPF), as well as αSMA inhibition.
UCHL1 inhibitor 27 (IMP-1711-S) is a powerful and selective probe to explore UCHL1 activity with potential application to substrate identification, mode of action studies, and cellular target profiling.
IMP-1711-S inhibited the production of IL-1β in a concentration-dependent manner in PMA-differentiated THP-1 cells and hiPSC-derived microglia.
IMP-1711-S potently inhibited gasdermin D (GSDMD) cleavage, the release of lactate dehydrogenase (LDH), and blocked pyroptotic cell death induced by Nig.
IMP-1711-S markedly downregulated the formation of NLRP3 specks in a concentration-dependent manner in HEK293 cells
| M.Wt | 357.417 | |
| Formula | C21H19N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kemp M, et al. WO 2017009650 (A1), 2017/01/19/, 2017.
2. Nattawadee Panyain, et al. J Am Chem Soc. 2020 Jul 15;142(28):12020-12026.
3. Zhu Liang, et al. Cell Rep. 2024 May 28;43(5):114152.
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