Chemical Structure : UR214-9
CAS No.:
2456263-31-1
UR214-9
Catalog No.: PC-27131Not For Human Use, Lab Use Only.
UR214-9 is a forchlorfenuron (FCF) analog and inhibitor of septin oligomeric assembly via preventing incorporation of SEPT2/7/9, into canonical hetero-octamers, decreases viability and proliferation in both ovarian and endometrial cancer cell lines, selectively suppress HER2 expression.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
UR214-9 is a forchlorfenuron (FCF) analog and inhibitor of septin oligomeric assembly via preventing incorporation of SEPT2/7/9, into canonical hetero-octamers, decreases viability and proliferation in both ovarian and endometrial cancer cell lines, selectively suppress HER2 expression.
UR214-9 decreases the expression of human epididymis protein 4 (HE4) in ECC-1 and HCH-1 cells.
UR214-9 (33 uM) selectively inhibits HER2 expression in both ECC-1 and HCH-1 cells, but not EGFR also suppress HER2 expression.
UR214-9 disrupts the incorporation of SEPT2, SEPT7, and SEPT9 into canonical septin hetero-octamers. causes defects in cytokinesis, altered cell migration, viability, and remodels septin-actin architectures, ultimately impairing tumor cell growth.
Physicochemical Properties
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M.Wt
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368.11
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Formula
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C13H7Cl2F4N3O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(2,6-dichloropyridin-4-yl)-3-(2-fluoro-3-(trifluoromethyl)phenyl)urea
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References
1. Kim KK, et al. Sci Rep. 2020 Feb 24;10(1):3241.
2. Khazan N, et al. bioRxiv [Preprint]. 2026 Jun 9:2026.06.09.731048.
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