Chemical Structure : USP10 inhibitor D1
CAS No.:
USP10 inhibitor D1
Catalog No.: PC-22313Not For Human Use, Lab Use Only.
USP10 inhibitor D1 is a potent, selective small molecule ubiquitin-specific protease 10 (USP10) inhibitor with IC50 of 7.2 uM, KD of 5.24 uM in microscale thermophoresis (MST)-based binding assay.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
USP10 inhibitor D1 is a potent, selective small molecule ubiquitin-specific protease 10 (USP10) inhibitor with IC50 of 7.2 uM, KD of 5.24 uM in microscale thermophoresis (MST)-based binding assay.
USP10 inhibitor D1 does not inhibit the deubiquitinase activity of USP7 at 10 uM.
USP10 inhibitor D1 inhibits the proliferation of hepatocellular carcinoma cell (Huh-7, IC50=2.3 uM) by inducing cell apoptosis and S-phase arrest.
USP10 inhibitor D1 inducing the degradation of USP10-related substrate protein by inhibiting USP10.
Physicochemical Properties
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M.Wt
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512.99
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Formula
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C29H25ClN4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-chlorophenethyl)-2-(7-methyl-4-oxo-3-(3-(o-tolyl)-1,2,4-oxadiazol-5-yl)quinolin-1(4H)-yl)acetamide
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References
1. Yang Lu, et al. Eur J Med Chem. 2024 May 5:272:116468.
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