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Chemical Structure : USP10 inhibitor D1
Catalog No.: PC-22313Not For Human Use, Lab Use Only.
USP10 inhibitor D1 is a potent, selective small molecule ubiquitin-specific protease 10 (USP10) inhibitor with IC50 of 7.2 uM, KD of 5.24 uM in microscale thermophoresis (MST)-based binding assay.
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USP10 inhibitor D1 is a potent, selective small molecule ubiquitin-specific protease 10 (USP10) inhibitor with IC50 of 7.2 uM, KD of 5.24 uM in microscale thermophoresis (MST)-based binding assay.
USP10 inhibitor D1 does not inhibit the deubiquitinase activity of USP7 at 10 uM.
USP10 inhibitor D1 inhibits the proliferation of hepatocellular carcinoma cell (Huh-7, IC50=2.3 uM) by inducing cell apoptosis and S-phase arrest.
USP10 inhibitor D1 inducing the degradation of USP10-related substrate protein by inhibiting USP10.
| M.Wt | 512.99 | |
| Formula | C29H25ClN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yang Lu, et al. Eur J Med Chem. 2024 May 5:272:116468.
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