You are here:Home-Chemical Inhibitors & Agonists-Proteasome/Ubiquitin-Deubiquitinase (DUB)-USP7 inhibitor ALM4
USP7 inhibitor ALM4

Chemical Structure : USP7 inhibitor ALM4

CAS No.: 2196243-57-7

USP7 inhibitor ALM4 (AD-04, (R)-USP-IN-4, USP7 inhibitor 4)

Catalog No.: PC-60003Not For Human Use, Lab Use Only.

USP7 inhibitor ALM4 (AD-04) is a highly potent, selective, allosteric USP7 inhibitor with IC50 of 6 nM in FP assays, SPR Kd of 2 nM.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    USP7 inhibitor ALM4 (AD-04) is a highly potent, selective, allosteric USP7 inhibitor with IC50 of 6 nM in FP assays, SPR Kd of 2 nM.
    AD-04 also shows high potency in an alternative assay using the Ub-Rh110 substrate (IC50=1.5 nM).
    AD-04 displays high selectivuty (>38-fold) against other DUBs, proteases and kinases.
    AD-04 demonstrates highly potent target engagement in cells (EC50=49 nM), with no off-target activity against USP47, causes nongenotoxic stabilization of p53 and decreased levels of MDM2 in HCT116 cells.

    Physicochemical Properties

    M.Wt 514.63
    Formula C29H34N6O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (R)-3-(4-(aminomethyl)phenyl)-6-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-2-methyl-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

    References

    1. Gavory G, et al. Nat Chem Biol. 2018 Feb;14(2):118-125.
    2. Anamarija Jurisic, et al. Clin Transl Med. 2024 Apr;14(4):e1648.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: