Udenafil (DA-8159) | PDE5 inhibitor | Probechem Biochemicals

Chemical Structure : Udenafil

CAS No.: 268203-93-6

Udenafil (DA-8159, DA8159)

Catalog No.: PC-45441Not For Human Use, Lab Use Only.

Udenafil (DA-8159) is a potent and selective phosphodiesterase 5 (PDE5) inhibitor, inhibits PDE5 activity in rabbit and human platelets with IC50 of 5.84 nM and 8.2 nM, respectively.

Packing	Price	Stock
10 mg	$98	In stock
25 mg	$158	In stock
50 mg	$248	In stock
100 mg	$398	In stock
250 mg	$3	In stock

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Biological Activity

Udenafil (DA-8159) is a potent and selective phosphodiesterase 5 (PDE5) inhibitor, inhibits PDE5 activity in rabbit and human platelets with IC50 of 5.84 nM and 8.2 nM, respectively.

Udenafil (DA-8159) inhibits PDE 5-catalyzed cGMP hydrolysis.

Udenafil (DA-8159) significantly stimulated the accumulation of cGMP.

Udenafil (DA-8159) displays> 100-fold selectivity over PDE 1, PDE 2, PDE 3 and PDE 6.

Udenafil (DA-8159) enhanced the relaxation of the smooth muscles in the normal rabbit corpus cavernosum.

Udenafil (DA-8159) induced a dose-dependent penile erection in diabetic rabbits.

Physicochemical Properties

M.Wt	516.6561
Formula	C25H36N6O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	Benzenesulfonamide, 3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]-4-propoxy-

References

1. Salem EA, et al. Curr Opin Investig Drugs. 2006 Jul;7(7):661-9.

2. Lee CH, et al. J Sex Med. 2010 Jul;7(7):2564-71.

3. Kang HE, et al. Br J Pharmacol. 2009 Mar;156(6):1009-18.

Udenafil (DA-8159, DA8159)

Biological Activity

Physicochemical Properties

References

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