Catalog No.: PC-50008Not For Human Use, Lab Use Only.
V-9302 (V9302) is a competitive, selective antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 with IC50 of 9.6 uM.
V-9302 (V9302) is a competitive, selective antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 with IC50 of 9.6 uM.
V-9302 displays 100-fold improvement in potency over γ-L-glutamyl-p-nitroanilide (GPNA).
V-9302 attenuates cancer cell growth and proliferation (CRC cell lines EC50=9-15 uM), increases cell death, and increases oxidative stress, which collectively contribute to antitumor responses in vitro and in vivo.
