Chemical Structure : VG081821AC
CAS No.:
2654051-66-6
VG081821AC
(VG081821 acetate)
Catalog No.: PC-25169Not For Human Use, Lab Use Only.
VG081821AC (VG081821 acetate) is a potent, selective, orally active A2A adenosine receptor antagonist with binding Ki of 0.85 nM, >300-fold selective over A1, A2B, and A3 receptors.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
VG081821AC (VG081821 acetate) is a potent, selective, orally active A2A adenosine receptor antagonist with binding Ki of 0.85 nM, >300-fold selective over A1, A2B, and A3 receptors.
VG081821 down-regulates intracellular cAMP levels by the cAMP TR-FRET assay with IC50 of 5.77 nM.
VG081821 is simultaneously a highly potent antagonist and inverse agonist of A2A receptor, has the inverse agonistic EC50 values of 0.74 nM.
VG081821 exhibits lower intrinsic clearance and superior pharmacokinetic profile compared to ZM241385.
Physicochemical Properties
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M.Wt
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452.48
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Formula
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C21H24N8O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(furan-2-yl)-N5-(4-(oxetan-3-ylamino)phenethyl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine acetate
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References
1. Sun S, et al. Drug Dev Res. 2025 Aug;86(5):e70133.
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