 
                Chemical Structure : VPC-23019
CAS No.: 449173-19-7
Catalog No.: PC-70075Not For Human Use, Lab Use Only.
VPC-23019 is a competitive S1P receptor antagonist with pKi of 7.86 and 5.93 for S1P1 and S1P3, respectively, in radioligand binding assays.
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	VPC-23019 is a competitive S1P receptor antagonist with pKi of 7.86 and 5.93 for S1P1 and S1P3, respectively, in radioligand binding assays.
	VPC-23019 increases the concentration-dependent vasoconstriction to S1P in both rat and mouse basilar arteries with intact endothelium.
| M.Wt | 372.4 | |
| Formula | C17H29N2O5P | |
| Appearance | Solid | |
| Storage | 
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| Solubility | 10 mM in DMSO | |
| Chemical Name/SMILES | (R)-2-amino-3-((3-octylphenyl)amino)-3-oxopropyl dihydrogen phosphate | |
1. Davis MD, et al. J Biol Chem. 2005 Mar 18;280(11):9833-41.
2. El-Shewy HM, et al. J Biol Chem. 2006 Oct 20;281(42):31399-407.
3. Salomone S, et al. Br J Pharmacol. 2008 Jan;153(1):140-7.

 
                 
                 
                 
                 
                 
                 
                 
                 
            
            
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