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Chemical Structure : VTP-27999 2,2,2-trifluoroacetate
CAS No.: 1013937-63-7
Catalog No.: PC-45865Not For Human Use, Lab Use Only.
A potent, highly selective renin inhibitor with IC50 of 0.47 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $1000 | In stock | |
| 100 mg | $1440 | In stock |
Bulk size, bulk discount!
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A potent, highly selective renin inhibitor with IC50 of 0.47 nM; displays >1000-fold selectivity for renin over a panel of >150 receptors, ion channels, and enzymes, and has an IC50 value >30 uM against CYP3A4; demonstrates >15% oral bioavailability in three species, oral efficacy in a double transgenic rat model of hypertension, and good exposure in humans.
Hypertension
Phase 1 Clinical
| M.Wt | 639.1039 | |
| Formula | C28H42ClF3N4O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Carbamic acid, N-[2-[(R)-(3-chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]-, methyl ester, 2,2,2-trifluoroacetate (1:1) |
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1. Jia L, et al. ACS Med Chem Lett. 2011 Aug 9;2(10):747-51.
2. Krop M, et al. Hypertension. 2013 May;61(5):1075-82.
3. Balcarek J, et al. Hypertension. 2014 May;63(5):942-50.
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