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VU-0357017 hydrochloride

Chemical Structure : VU-0357017 hydrochloride

CAS No.: 1135242-13-5

VU-0357017 hydrochloride (VU0357017 hydrochloride)

Catalog No.: PC-45705Not For Human Use, Lab Use Only.

VU-0357017 hydrochloride is a subtype-selective allosteric agonist of M1 receptor with EC50 of 198 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

VU-0357017 hydrochloride is a subtype-selective allosteric agonist of M1 receptor with EC50 of 198 nM.
VU-0357017 displays good selectivity versus M2-M5 and a large panel of GPCRs, ion channels, and transporters.
VU-0357017 shows excellent brain exposure and robust in vivo efficacy in rodent model.

Physicochemical Properties

M.Wt 369.8862
Formula C18H28ClN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 33 mg/mL

Chemical Name/SMILES

1-Piperidinecarboxylic acid, 4-[[2-[(2-methylbenzoyl)amino]ethyl]amino]-, ethyl ester, hydrochloride (1:1)

References

1. Lebois EP, et al. ACS Chem Neurosci. 2010;1(2):104-121.

2. Digby GJ, et al. J Neurosci. 2012 Jun 20;32(25):8532-44.

3. Digby GJ, et al. ACS Chem Neurosci. 2012 Dec 19;3(12):1025-36.

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