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Chemical Structure : VU-0357017 hydrochloride
CAS No.: 1135242-13-5
Catalog No.: PC-45705Not For Human Use, Lab Use Only.
VU-0357017 hydrochloride is a subtype-selective allosteric agonist of M1 receptor with EC50 of 198 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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VU-0357017 hydrochloride is a subtype-selective allosteric agonist of M1 receptor with EC50 of 198 nM.
VU-0357017 displays good selectivity versus M2-M5 and a large panel of GPCRs, ion channels, and transporters.
VU-0357017 shows excellent brain exposure and robust in vivo efficacy in rodent model.
| M.Wt | 369.8862 | |
| Formula | C18H28ClN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
1-Piperidinecarboxylic acid, 4-[[2-[(2-methylbenzoyl)amino]ethyl]amino]-, ethyl ester, hydrochloride (1:1) |
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1. Lebois EP, et al. ACS Chem Neurosci. 2010;1(2):104-121.
2. Digby GJ, et al. J Neurosci. 2012 Jun 20;32(25):8532-44.
3. Digby GJ, et al. ACS Chem Neurosci. 2012 Dec 19;3(12):1025-36.
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