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Chemical Structure : VX-702
CAS No.: 745833-23-2
Catalog No.: PC-42563Not For Human Use, Lab Use Only.
VX-702 is a potent, selective, second generation p38 MAPK inhibitor with IC50 of 4-20 nM for p38α.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
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VX-702 is a potent, selective, second generation p38 MAPK inhibitor with IC50 of 4-20 nM for p38α.
VX-702 displays 14-fold higher potency against the p38α versus p38β.
VX-702 inhibits p38 activation induced by platelet agonists including thrombin, SFLLRN, AYPGKF, U46619 and collagen, without effect on collagen-mediated platelet aggregation.
| M.Wt | 404.3178 | |
| Formula | C19H12F4N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 42 mg/mL |
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| Chemical Name/SMILES |
3-Pyridinecarboxamide, 6-[(aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)- |
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1. Kuliopulos A, et al. Thromb Haemost. 2004 Dec;92(6):1387-93.
2. Damjanov N, et al. Arthritis Rheum. 2009 May;60(5):1232-41.
3. Ding C. Curr Opin Investig Drugs. 2006 Nov;7(11):1020-5.
4. Matsushita T, et al. Am J Pathol. 2017 Apr;187(4):841-850.
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