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Chemical Structure : Vanoxerine
Catalog No.: PC-43400Not For Human Use, Lab Use Only.
Vanoxerine (GBR-12909, I-893, Boxeprazine) is a highly potent inhibitor of dopamine uptake in vitro in tissue slices obtained from rat neostriatum with IC50 of 40-50 nM, also inhibits norepinephrine uptake with IC50 of 560-2600 nM.
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Vanoxerine (GBR-12909, I-893, Boxeprazine) is a highly potent inhibitor of dopamine uptake in vitro in tissue slices obtained from rat neostriatum with IC50 of 40-50 nM, also inhibits norepinephrine uptake with IC50 of 560-2600 nM.
Vanoxerine also is a potent hK(v)11.1 blocker, and at submicromolar concentrations.
Vanoxerine blocks Ca and Na currents in a strongly frequency-dependent manner possesses anticonvulsant activity in zebrafish and rodent models of generalized epilepsy but with cardiac ion channel effects.
Vanoxerine also is a cancer-specific downregulator of G9a expression, suppresses cancer stem cell functions in colon tumors.
| M.Wt | 450.5633 | |
| Formula | C28H32F2N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Teicher MH, et al. Brain Res. 1986 Nov;395(1):124-8.
2. Heikkila RE, et al. Eur J Pharmacol. 1984 Aug 17;103(3-4):241-8.
3. Lacerda AE, et al. J Cardiovasc Electrophysiol. 2010 Mar;21(3):301-10.
4. Goldsmith P, et al. Pharmacology. 2007;79(4):250-8.
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