Vanoxerine dihydrochloride | Dopamine transport inhibitor

Chemical Structure : Vanoxerine dihydrochloride

CAS No.: 67469-78-7

Vanoxerine dihydrochloride (Boxeprazine, GBR-12909, GBR12909;I893, I-893)

Catalog No.: PC-43399Not For Human Use, Lab Use Only.

Vanoxerine (GBR-12909, I-893, Boxeprazine) is a highly potent inhibitor of dopamine uptake in vitro in tissue slices obtained from rat neostriatum with IC50 of 40-50 nM, also inhibits norepinephrine uptake with IC50 of 560-2600 nM.

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50 mg	$78	In stock
100 mg	$118	In stock
250 mg	$198	In stock
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Biological Activity

Vanoxerine (GBR-12909, I-893, Boxeprazine) is a highly potent inhibitor of dopamine uptake in vitro in tissue slices obtained from rat neostriatum with IC50 of 40-50 nM, also inhibits norepinephrine uptake with IC50 of 560-2600 nM.

Vanoxerine also is a potent hK(v)11.1 blocker, and at submicromolar concentrations.

Vanoxerine blocks Ca and Na currents in a strongly frequency-dependent manner possesses anticonvulsant activity in zebrafish and rodent models of generalized epilepsy but with cardiac ion channel effects.

Vanoxerine also is a cancer-specific downregulator of G9a expression, suppresses cancer stem cell functions in colon tumors.

Physicochemical Properties

M.Wt	450.5633
Formula	C28H32F2N2O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: 9.4 mg/mL
Chemical Name/SMILES	Piperazine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)-, hydrochloride (1:2)

References

1. Teicher MH, et al. Brain Res. 1986 Nov;395(1):124-8.

2. Heikkila RE, et al. Eur J Pharmacol. 1984 Aug 17;103(3-4):241-8.

3. Lacerda AE, et al. J Cardiovasc Electrophysiol. 2010 Mar;21(3):301-10.

4. Goldsmith P, et al. Pharmacology. 2007;79(4):250-8.

Vanoxerine dihydrochloride (Boxeprazine, GBR-12909, GBR12909;I893, I-893)

Biological Activity

Physicochemical Properties

References

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