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Chemical Structure : Vemurafenib
CAS No.: 918504-65-1
Catalog No.: PC-42871Not For Human Use, Lab Use Only.
Vemurafenib (PLX4032, RG7204, RO5185426) is a potent, selective B-RAF V600E inhibitor with IC50 of 30 nM, displays similar potency for c-RAF-1 (IC50=48 nM), and has selectivity against many other kinases, including wild type B-RAF (IC50=100nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $68 | In stock | |
| 100 mg | $128 | In stock | |
| 250 mg | $198 | In stock | |
| 1 g | Get quote |
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Vemurafenib (PLX4032, RG7204, RO5185426) is a potent, selective B-RAF V600E inhibitor with IC50 of 30 nM, displays similar potency for c-RAF-1 (IC50=48 nM), and has selectivity against many other kinases, including wild type B-RAF (IC50=100nM).
Vemurafenib (PLX4032) potently inhibits proliferation of a panel of tumor cell lines, selectively blocks the RAF/MEK/ERK pathway in BRAF mutant cells.
Vemurafenib (PLX4032) causes tumor regressions and improves animal survival in tumor xenograft models of BRAF(V600E)-expressing melanoma.
| M.Wt | 489.9221 | |
| Formula | C23H18ClF2N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 6.2 mg/mL |
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| Chemical Name/SMILES |
1-Propanesulfonamide, N-[3-[[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]- |
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1. Bollag G, et al. Nature. 2010 Sep 30;467(7315):596-9.
2. Joseph EW, et al. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14903-8.
3. Yang H, et al. Cancer Res. 2010 Jul 1;70(13):5518-27.
4. Søndergaard JN, et al. J Transl Med. 2010 Apr 20;8:39.
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