You are here:Home-Chemical Inhibitors & Agonists-Tyrosine Kinase-c-Fms (CSF1R)-Vimseltinib
Vimseltinib

Chemical Structure : Vimseltinib

CAS No.: 1628606-05-2

Vimseltinib (DCC-3014, DCC3014)

Catalog No.: PC-38376Not For Human Use, Lab Use Only.

Vimseltinib (DCC-3014) is a potent, selective, orally active inhibitor of colony-stimulating factor 1 receptor (CSF1R/c-Fms), inhibits CSF1R phosphorylated juxtamembrane domain (JMD) with IC50 of 2.8 nM, 100-fold less potency against fully phosphorylated CSF1R (IC50=290 nM).

Packing Price Stock Quantity
5 mg $258 In stock
25 mg $598 In stock
100 mg $1480 In stock
200 mg Get quote
1 g Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Vimseltinib (DCC-3014) is a potent, selective, orally active inhibitor of colony-stimulating factor 1 receptor (CSF1R/c-Fms), inhibits CSF1R phosphorylated juxtamembrane domain (JMD) with IC50 of 2.8 nM, 100-fold less potency against fully phosphorylated CSF1R (IC50=290 nM).
Vimseltinib (DCC-3014) exhibits approximately 20-fold weaker affinity for unphosphorylated CSF1R (Kd=79 nM) versus the JMD phosphorylated form (Kd=3.6 nM).
Vimseltinib (DCC-3014) displays high selectivity (>100-fold) for CSF1R kinase against a panel of approximately 300 human kinases.
Vimseltinib (DCC-3014) potently inhibited CSF1-stimulated phosphorylation of CSF1R in the human THP1 mononuclear cell line with IC50 of 19 nM, inhibited proliferation of M-NFS-60 cells with IC50 of 10.1 nM.
Vimseltinib (DCC-3014) inhibited CSF1R signaling in monocytes in human whole blood with an average IC50 of 403 nM, as measured the levels of phosphorylated ERK (downstream of CSF1R activation).
Vimseltinib (DCC-3014) inhibited tumor growth and bone degradation in mouse cancer models.

Physicochemical Properties

M.Wt 431.500
Formula C23H25N7O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(isopropylamino)-3-methyl-5-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)pyrimidin-4(3H)-one

References

1. Smith BD, et al. Mol Cancer Ther. 2021 Nov;20(11):2098-2109.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: