Vofopitant dihydrochloride
(GR205171A, GR 205171A, GR-205171A)
Catalog No.: PC-23398Not For Human Use, Lab Use Only.
Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1 receptor (NK1R) antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively.
Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1 receptor (NK1R) antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively.
Vofopitant prevents vagal stimulation-induced retching but not neuronal transmission from emetic vagal afferents to solitary nucleus neurons in dogs.
Vofopitant exhibits an acute response to cisplatin but does not vomit during the delayed phase.
