Chemical Structure : WMJ-J-09
CAS No.:
2416914-29-7
WMJ-J-09
Catalog No.: PC-24736Not For Human Use, Lab Use Only.
WMJ-J-09 a potent, hydroxamate based HDAC inhibitor, exhibits potent inhibitory activity against class I HDACs, including HDAC1 (IC50=7.5 nM), HDAC2 (IC50=21.3 nM), HDAC3 (IC50=18.4 nM), and HDAC8 (IC50=90.9 nM), also strongly inhibitsHDAC6 (class IIb) with IC50 of 3.9 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
WMJ-J-09 a potent, hydroxamate based HDAC inhibitor, exhibits potent inhibitory activity against class I HDACs, including HDAC1 (IC50=7.5 nM), HDAC2 (IC50=21.3 nM), HDAC3 (IC50=18.4 nM), and HDAC8 (IC50=90.9 nM), also strongly inhibitsHDAC6 (class IIb) with IC50 of 3.9 nM.
WMJ-J-09 arrests the cell cycle and induced apoptosis in HCT116 cells.
WMJ-J-09 shows moderate inhibition toward HDAC4 (class IIa) with an IC50 of 8715.7 nM.
WMJ-J-09 significantly reduces the polymerized tubulin fraction through HDAC inhibition.
WMJ-J-09 caused HCT116 cell death may involve p21 elevation and survivin suppression.
WMJ-J-09 triggers LKB1-p38MAPK-p53 signaling pathway to increases p21 expression and survivin reduction, culminating in HCT116 cell death.
WMJ-J-09 induced survivin degradation.
WMJ-J-09 (20 mg/kg/day) inhibits growth of the HCT116 tumor xenograft, does not impact mouse body weight.
Physicochemical Properties
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M.Wt
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445.53
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Formula
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C22H27N3O5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N1-hydroxy-N8-(1-(phenylsulfonyl)indolin-6-yl)octanediamide
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References
1. Yen CS, et al. Front Pharmacol. 2018 Mar 1;9:167.
2. Huang YH, et al. Sci Rep. 2025 Jun 4;15(1):19590.
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