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Chemical Structure : WQ-C-401
Catalog No.: PC-22702Not For Human Use, Lab Use Only.
WQ-C-401 is a highly potent, selective PDGFR inhibitor, inhibits PDGFRα/β autophosphorylation in PDGFRα/β wt-transformed BaF3 isogenic cells with IC50 of 3/11 nM respectively.
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WQ-C-401 is a highly potent, selective PDGFR inhibitor, inhibits PDGFRα/β autophosphorylation in PDGFRα/β wt-transformed BaF3 isogenic cells with IC50 of 3/11 nM respectively.
WQ-C-401 exhibits good selectivity for PDGFR (S score (1) = (0.01) at a concentration of 1 μM.
WQ-C-401 also exhibits binding affinity for the kinases cKIT and CSF1R, but only moderately inhibits CSF1R (GI50 = 0.13 μM) and does not affect tel-cKIT-BaF3 cells (GI50 > 10 μM).
WQ-C-401 (1 uM) decreased PDGF-BB-induced migration in a concentration-dependent manner in human PASMCs.
WQ-C-401 (25, 50, 100 mg/kg/d) significantly attenuated MCT-induced pulmonary artery hypertrophy, suppressed MCT-induced cell hyperproliferation and CD68+ macrophage infiltration around the pulmonary artery.
| M.Wt | 418.50 | |
| Formula | C24H26N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Huang W, et al. xp Cell Res. 2024 Jul 10:114154.
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