Chemical Structure : WQ-C-401
CAS No.:
2376694-72-1
WQ-C-401
Catalog No.: PC-22702Not For Human Use, Lab Use Only.
WQ-C-401 is a highly potent, selective PDGFR inhibitor, inhibits PDGFRα/β autophosphorylation in PDGFRα/β wt-transformed BaF3 isogenic cells with IC50 of 3/11 nM respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
WQ-C-401 is a highly potent, selective PDGFR inhibitor, inhibits PDGFRα/β autophosphorylation in PDGFRα/β wt-transformed BaF3 isogenic cells with IC50 of 3/11 nM respectively.
WQ-C-401 exhibits good selectivity for PDGFR (S score (1) = (0.01) at a concentration of 1 μM.
WQ-C-401 also exhibits binding affinity for the kinases cKIT and CSF1R, but only moderately inhibits CSF1R (GI50 = 0.13 μM) and does not affect tel-cKIT-BaF3 cells (GI50 > 10 μM).
WQ-C-401 (1 uM) decreased PDGF-BB-induced migration in a concentration-dependent manner in human PASMCs.
WQ-C-401 (25, 50, 100 mg/kg/d) significantly attenuated MCT-induced pulmonary artery hypertrophy, suppressed MCT-induced cell hyperproliferation and CD68+ macrophage infiltration around the pulmonary artery.
Physicochemical Properties
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M.Wt
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418.50
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Formula
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C24H26N4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-methyl-3-((1-(1-methyl-1H-imidazole-4-carbonyl)piperidin-4-yl)oxy)phenyl)benzamide
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References
1. Huang W, et al. xp Cell Res. 2024 Jul 10:114154.
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