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WS3

Chemical Structure : WS3

CAS No.: 1421227-52-2

WS3 (β cells proliferation inducer)

Catalog No.: PC-43044Not For Human Use, Lab Use Only.

WS3 is a small molecule that can induce proliferation of β cells with EC50 of 74 nM, modulates the activity of Erb3 binding protein-1 and the IκB kinase pathway.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

WS3 is a small molecule that can induce proliferation of β cells with EC50 of 74 nM, modulates the activity of Erb3 binding protein-1 and the IκB kinase pathway.
WS3 can reversibly proliferates primary RPE cells isolated from fetal and adult human donors.

Physicochemical Properties

M.Wt 569.5781
Formula C28H30F3N7O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 43 mg/mL

Chemical Name/SMILES

Cyclopropanecarboxamide, N-[6-[4-[[[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-

References

1. Swoboda JG, et al. ACS Chem Biol. 2013 Jul 19;8(7):1407-11.

2. Shen W, et al. J Am Chem Soc. 2013 Feb 6; 135(5):1669-72.

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