WT161 (WT-161) is a potent, selective, and bioavailable HDAC6 inhibitor with IC50 0.4 nM.
WT161 displays >20-fold selectivity over HDAC1/2/3/8.
WT161 selectively inhibits HDAC6 and dramatically increases levels of acetylated α-tubulin with little effect on global lysine acetylation in cells.
WT161 reversibly and rapidly induces the accumulation of Ac-α-tubulin in MM cell lines, displays synergism with both BTZ and CFZ, caspase activation and apoptosis.
WT161 demonstrates a significant antitumor effect in human MM cell xenograft mouse model combined with BTZ.
