WX-340 | uPA inhibitor | Probechem Biochemicals

Chemical Structure : WX-340

WX-340 (WX340, Cyclo21,29 [D-Cys21 Cys29]-uPA21-30)

Catalog No.: PC-49100Not For Human Use, Lab Use Only.

WX-340 is a highly specific and selective, peptidic cyclic competitive inhibitor of urokinase-type plasminogen activator (uPA) with Ki of 12 and 170 nM for human and mouse uPA, respectively, inhibits 10 Units of human uPA with IC50 of 90 nM.

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Biological Activity

WX-340 is a highly specific and selective, peptidic cyclic competitive inhibitor of urokinase-type plasminogen activator (uPA) with Ki of 12 and 170 nM for human and mouse uPA, respectively, inhibits 10 Units of human uPA with IC50 of 90 nM.
WX-340 blocks uPA‐PAI‐1 heteromerization, significantly increases the proliferation of 4T1 cells.
WX‐340 significantly reduces neutrophil trafficking to the neoplasms already on the level of intravascular adherence in the tumor microvaculature.
WX-340 reduces cell adhesion and invasiveness in a dose-dependent manner in anaplastic thyroid carcinoma (ATC) derived cell lines, CAL-62 and BHT-101, WX-340 increases uPA receptor (uPAR) protein levels without affecting its plasma membrane concentration.
WX-340 (10 mg/kg, i.p.) prolonged (p<0.05) survival of animal modesl of amyotrophic lateral sclerosis (ALS), as well as improving rotarod performance.

Physicochemical Properties

M.Wt	1275.465
Formula	C58H78N14O15S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((4R,7R,10S,13S,16S,19S,22S,25S,28S)-28-amino-10,25-bis(2-amino-2-oxoethyl)-22-(4-aminobutyl)-16-benzyl-7-((S)-sec-butyl)-19-(4-chlorobenzyl)-13-(hydroxymethyl)-6,9,12,15,18,21,24,27-octaoxo-1,2-dithia-5,8,11,14,17,20,23,26-octaazacyclononacosane-4-carbonyl)-L-tryptophan

References

1. Glas M, et al. Exp Neurol. 2007 Oct;207(2):350-6.

2. Serratì S, et al. Arthritis Rheum. 2011 Sep;63(9):2584-94.

3. Bernd Uhl, et al. EMBO Mol Med. 2021 Jun 7;13(6):e13110.

4. Baldini E, et al. Int J Mol Sci. 2022 Mar 28;23(7):3724.

WX-340 (WX340, Cyclo21,29 [D-Cys21 Cys29]-uPA21-30)

Biological Activity

Physicochemical Properties

References

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