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Chemical Structure : YAP activator PY-60
CAS No.: 2765218-56-0
Catalog No.: PC-38304Not For Human Use, Lab Use Only.
YAP activator PY-60 (PY-60) is a novel small molecule activator of YAP transcriptional activity (EC50=1.5 uM) via targeting annexin A2 (ANXA2).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $498 | In stock | |
| 25 mg | $798 | In stock | |
| 100 mg | Get quote |
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YAP activator PY-60 (PY-60) is a novel small molecule activator of YAP transcriptional activity (EC50=1.5 uM) via targeting annexin A2 (ANXA2).
PY-60 dose-dependently induced luciferase activity in 293A-TEAD-LUC cells, robustly activateed YAP transcriptional activity in vitro.
PY-60 treatment robustly increased the levels of YAP-controlled transcripts (ANRKD1, CYR61 and CTGF) in 293A cells and other human cell lines (MCF10A, HEK293T, H69 and HaCaT), but did not augment the levels of YAP itself (YAP1).
PY-60 promotes YAP-dependent expansion of epidermal keratinocytes in mouse following topical drug administration. Annexin A2 (ANXA2) is a protein that directly associates with YAP at the cell membrane in response to increased cell density.
PY-60 treatment liberates ANXA2 from the membrane, ultimately promoting a phosphatase-bound, nonphosphorylated and transcriptionally active form of YAP.
| M.Wt | 313.375 | |
| Formula | C16H15N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-phenyl-N-(3-(thiazol-2-yl)propyl)isoxazole-3-carboxamide |
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1. Shalhout SZ, et al. Nat Chem Biol. 2021 Jul;17(7):767-775.
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