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Chemical Structure : YK-2-69
Catalog No.: PC-38751Not For Human Use, Lab Use Only.
YK-2-69 is a potent, hilghly selective inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) with IC50 value of 9 nM, shows weak inhibition against DYRK1B (IC50=542 nM) and no activity against DYRK1A/3/4 (IC50>1,000 nM).
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YK-2-69 is a potent, hilghly selective inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) with IC50 value of 9 nM, shows weak inhibition against DYRK1B (IC50=542 nM) and no activity against DYRK1A/3/4 (IC50>1,000 nM).
YK-2-69 specifically interacts with Lys-231 and Lys-234 of DYRK2.
YK-2-69 remarkably reduces PCa burden in vitro and in vivo.
YK-2-69 exhibits more potent anti-PCa efficacy than the first-line drug enzalutamide in vivo.
YK-2-69 displays favorable safety properties with a maximal tolerable dose of more than 10,000 mg/kg and pharmacokinetic profiles with 56% bioavailability.
| M.Wt | 506.604 | |
| Formula | C25H27FN8OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yuan K, et al. Nat Commun. 2022 May 25;13(1):2903.
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