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Chemical Structure : YSR734
Catalog No.: PC-21520Not For Human Use, Lab Use Only.
YSR734 is a first-in-class covalent HDACs inhibitor with IC50 of 0.109 uM, 0.154 uM and 0.143 uM for HDAC1, HDAC2, and HDAC3, sparing other deacetylases (HDAC4-HDAC10, IC50>10 uM).
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YSR734 is a first-in-class covalent HDACs inhibitor with IC50 of 0.109 uM, 0.154 uM and 0.143 uM for HDAC1, HDAC2, and HDAC3, sparing other deacetylases (HDAC4-HDAC10, IC50>10 uM).
YSR734 shows weak activity against class IV HDAC11 (IC50 > 2000 nM).
YSR734 shows potent biological activity against MV4-11 and RS4;11 with IC50 of 0.53 and 1.00 uM, respectively, but not non-cancerous MRC-9 cells (IC50=20 uM).
YSR734 (0.5-5.0 uM) caused an increase in Ac-histone-H3 in MV4-11 cells, with no effect against Ac-α-tubulin (HDAC6), suggesting class I HDAC selectivity.
YSR734 (5 uM) potently induced myoblast differentiation as shown by upregulation of Cav3, myogenin, and Ac-α-tubulin, induced the formation of myotubes from myoblasts.
| M.Wt | 598.55 | |
| Formula | C26H23F5N4O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yasir S Raouf, et al. J Med Chem. 2023 Dec 7. doi: 10.1021/acs.jmedchem.3c01236.
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