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Chemical Structure : Z-944
CAS No.: 1199236-64-0
Catalog No.: PC-62009Not For Human Use, Lab Use Only.
Z-944 (Ulixacaltamide) is a potent, highly selective and oral T-type calcium channel blocker with IC50 of 50-160 nM for human Cav3.1, Cav3.2, and Cav3.3 channels.
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|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
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Z-944 (Ulixacaltamide) is a potent, highly selective and oral T-type calcium channel blocker with IC50 of 50-160 nM for human Cav3.1, Cav3.2, and Cav3.3 channels.
Z-944 (Ulixacaltamide) displays 70 times more potent for T-type blockade than for blockade of the N-type channel (IC50=11 uM).
Z-944 (Ulixacaltamide) potently suppress seizure activity and attenuates burst firing of thalamic reticular nucleus neurons in the GAERS model of absence epilepsy.
Z-944 (Ulixacaltamide) restores cortical synchrony and thalamocortical connectivity in a rat model of neuropathic pain.
| M.Wt | 383.89 | |
| Formula | C19H27ClFN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[[1-[2-(tert-butylamino)-2-oxoethyl]piperidin-4-yl]methyl]-3-chloro-5-fluorobenzamide |
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1. Tringham E, et al. Sci Transl Med. 2012 Feb 15;4(121):121ra19.
2. Casillas-Espinosa PM, et al. PLoS One. 2015 Aug 14;10(8):e0130012.
3. LeBlanc BW, et al. Pain. 2016 Jan;157(1):255-63.
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