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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-HCN Channel-ZD-7288
ZD-7288

Chemical Structure : ZD-7288

CAS No.: 133059-99-1

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ZD-7288 (ICI-D 7288, ZD7288)

Catalog No.: PC-70127Not For Human Use, Lab Use Only.

ZD-7288 (ICI-D 7288) is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ZD-7288 (ICI-D 7288) is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker.
ZD-7288 inhibits the hyperpolarization activated cationic current (If) in a concentration-dependent manner in rat brain.

Physicochemical Properties

M.Wt 292.81
Formula C15H21ClN4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-N-ethyl-1,2-dimethyl-6-(methylimino)-N-phenyl-1,6-dihydropyrimidin-4-amine hydrochloride

References

1. Zhang XX, et al. Neural Regen Res. 2016 May;11(5):779-86.

2. Guli X, et al. Neural Plast. 2012;2012:237913.

3. BoSmith RE, et al. Br J Pharmacol. 1993 Sep;110(1):343-9.

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