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Chemical Structure : ZYF0033
CAS No.: 2380300-79-6
Catalog No.: PC-72305Not For Human Use, Lab Use Only.
ZYF0033 (ZYF 0033) is potent, selective, small-molecule inhibitor of HPK1 (MAP4K1) with IC50 of <10 nM based on the phosphorylation inhibition of MBP protein.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $318 | In stock | |
| 25 mg | $528 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ZYF0033 (ZYF 0033) is potent, selective, small-molecule inhibitor of HPK1 (MAP4K1) with IC50 of <10 nM based on the phosphorylation inhibition of MBP protein.
ZYF0033 successfully decreased the phosphorylation of SLP76 (serine 376), a critical biomarker of T cell and HPK1 activation.
ZYF0033 promoted anticancer immune responses, inhibited tumor growth and caused increased intratumoral infiltration of DCs, NK cells, and CD107a+CD8+ T cells but decreased infiltration of regulatory T cells, PD-1+CD8+ T cells, TIM-3+CD8+ T cells, and LAG-3+CD8+ T cells in the 4T-1 syngeneic mouse model.
ZYF0033 significantly increased the proliferation of CD4+ and CD8+ T cells (Figure S7I) and the secretion of IFN-γ in bone-marrow-derived DCs.
| M.Wt | 462.612 | |
| Formula | C26H30N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-Butyn-2-ol, 4-[3-[[[2-amino-5-[2-(1-methyl-4-piperidinyl)-5-thiazolyl]-3-pyridinyl]oxy]methyl]phenyl]-2-methyl- |
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1. Jingwen Si, et al. Cancer Cell. 2020 Oct 12;38(4):551-566.e11.
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