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Chemical Structure : Zanubrutinib
CAS No.: 1691249-45-2
Catalog No.: PC-60535Not For Human Use, Lab Use Only.
Zanubrutinib (BGB3111) is a potent, selective and orally available Btk inhibitor with IC50 of 0.3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Zanubrutinib (BGB3111) is a potent, selective and orally available Btk inhibitor with IC50 of 0.3 nM.
Zanubrutinib (BGB3111) shows much more restricted off-target activities against a panel of kinases, including ITK, compared with Ibrutinib.
Zanubrutinib (BGB3111) demonstrates nanomolar BTK inhibition activity, inhibits BCR aggregation-triggered BTK autophosphorylation, blocks downstream PLC-γ2 signaling, and potently inhibits cell proliferation in several MCL and DLBCL cell lines.
Zanubrutinib (BGB3111) demonstrates better anti-tumor activity than ibrutinib in TMD-8 subcutaneous xenograft model.
| M.Wt | 471.561 | |
| Formula | C27H29N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(7S)-4,5,6,7-Tetrahydro-7-[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide |
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1. Na Li, et al. Abstract 2597: BGB-3111 is a novel and highly selective Bruton's tyrosine kinase (BTK) inhibitor. AACR.
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